Journal of pharmacological and toxicological methods
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J Pharmacol Toxicol Methods · Mar 2004
Determination of interstitial rocuronium concentrations in the muscle tissue of anesthetized dogs by microdialysis.
The objective was to establish and validate a microdialysis technique for the quantification of interstitial concentrations of the neuromuscular blocker, rocuronium, in the muscle tissue of dogs under steady-state conditions. ⋯ Combined retrodialysis is a more reliable and accurate technique for quantitative assessment of rocuronium interstitial concentrations especially for lengthy anesthetic procedures. These findings have potential implications, as drug concentrations in the site of action would be more relevant for concentration-effect relation of muscle relaxants.