Paediatric anaesthesia
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[corrected] Volumetric infusion pumps are widely used in paediatric practice. Tissue extravasation is a hazard. The occlusion pressure limit alarm, although not intended to detect extravasation, is the only warning sign present to indicate flow faults in the infusion systems. ⋯ Occlusion pressure limit alarm cannot reliably detect extravasation especially at sites with high compliance, low flow rates, even at low occlusion limit. Line pressure depends on interplay of site (compliance) and flow rate and is independent of volume extravasated. Users must be aware of the set occlusion pressure limit. Repeated clinical assessment remains vital.
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Paediatric anaesthesia · Nov 2002
Repeated administration of ketamine may lead to neuronal degeneration in the developing rat brain.
This study was conducted to investigate, in vivo, the dose and duration effects of ketamine administration on neuronal degeneration in the developing rat brain. ⋯ These findings suggest that the duration of ketamine exposure correlates with increased neuronal degeneration in the developing rat brain.
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Paediatric anaesthesia · Nov 2002
Letter Case ReportsCytochrome P450 pharmacogenetics and anaesthesia.