Surgical oncology
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Observational Study
Drainage after distal pancreatectomy: Still an unsolved problem.
The use of intraperitoneal drainage after distal pancreatectomy is still controversial. Its use increases fistula risk, but its absence increases the severity of the fistula. Therefore, since 2014, we have systematically used two drains. ⋯ Since changing the drainage strategy, we have observed a dramatic decrease in pancreatic abscess formation and fluid collections needing percutaneous drainage. The results of this study show that the strategy of double drainage after distal pancreatectomy may reduce the severity of POPF, thus avoiding reoperation or further interventions.
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To develop and validate a radiomics-based nomogram for the preoperative prediction of posthepatectomy liver failure (PHLF) in patients with hepatocellular carcinoma (HCC). ⋯ A nomogram based on the Rad-score, MELD, and PS can predict PHLF.
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Gastric cancer with the presence of peritoneal metastases (pmgc) is associated with a very poor prognosis. Despite the wide utilization and promising results of the multimodal treatment regimens including cytoreductive surgery (CRS) and a subsequent hyperthermic intraperitoneal chemotherapy (HIPEC), it is still not fully understood which patient group is suitable for this treatment. ⋯ Neoadjuvant chemotherapy using the FLOT-protocol followed by CRS + HIPEC seems to be associated with prolonged OS in patients with peritoneal carcinomatosis from gastric cancer. This treatment needs a critical evaluation for patients with a PCI ≥12. Furthermore, the accurate selection of patients suffering of PMGC by using the developed score can improve the OS of up to 24 months for a suitable group and it can avoid the extensive treatment for unsuitable patients.
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Glioblastoma multiforme (GBM) are aggressive brain tumors, which lead to poor overall survival (OS) of patients. OS prediction of GBM patients provides useful information for surgical and treatment planning. Radiomics research attempts at predicting disease prognosis, thus providing beneficial information for personalized treatment from a variety of imaging features extracted from multiple MR images. ⋯ The shape features used in this work have been evaluated for OS prediction of GBM patients for the first time. The feature selection and prediction scheme implemented in this study yielded high accuracy for both 2-class and 3-class OS group predictions. This study was performed using routinely acquired MR images for GBM patients, thus making the translation of this work into a clinical setup convenient.
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Laparoscopic liver resection (LLR) has gained significant popularity over the last 10 years. First experiences of LLR compared to open liver resection (OLR) reported a similar survival and a better safety profile for LLR. ⋯ Minor LLR appeared significantly safer compared to minor OLR for HCC. LLR was associated with fewer post-operative complication, lower operative blood loss and a shorter hospital stay along with similar survival and recurrence-free survival rates.