Pharmacoepidemiology and drug safety
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Pharmacoepidemiol Drug Saf · Mar 2006
Comparative StudyAdverse effects of neuromuscular blocking agents based on yellow card reporting in the U.K.: are there differences between males and females?
Adverse drug reactions (ADRs) are known to occur during anaesthesia; in the U.K. such ADRs may be reported through the Yellow Card Scheme (YCS). Our aim was to determine the demographics of ADRs to neuromuscular blocking drugs without formal causality assessment. ⋯ Sex differences in mortality exist in this analysis. The unexpected high frequency of non-allergic ADRs suggests that morbidity and mortality from reactions to established drugs is twice that expected from allergic reactions alone. Standards and guidance for the reporting of ADRs warrant urgent development.