Pharmacoepidemiology and drug safety
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Pharmacoepidemiol Drug Saf · Dec 2012
Prevalence and correlates of exceeding the labeled maximum dose of acetaminophen among adults in a U.S.-based internet survey.
Acetaminophen is a commonly used analgesic; excessive doses can lead to liver damage. We sought to determine the proportion of acetaminophen users exceeding the recommended maximum daily dose of 4 g and identify correlates of such behavior. ⋯ The results estimate the proportion of acetaminophen users exceeding 4 g in a group of U.S. adults, identify potentially modifiable attitudes and knowledge associated with such use, and characterize subpopulations at higher risk.
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Pharmacoepidemiol Drug Saf · Dec 2012
Influence of prescription monitoring programs on analgesic utilization by an insured retiree population.
To estimate the association between prescription drug monitoring programs (PDMP) and the probability of analgesic use, overall and by analgesic type. ⋯ PDMPs are associated with reductions in utilization of targeted prescription OAs and increases in less scrutinized, lower scheduled OAs. Longitudinal studies are needed to determine how PDMPs shift analgesic prescribing and whether such shifts influence clinical care and economic outcomes.