Pharmacoepidemiology and drug safety
-
Pharmacoepidemiol Drug Saf · Oct 2016
Meta Analysis Comparative StudyIndividual-based versus aggregate meta-analysis in multi-database studies of pregnancy outcomes: the Nordic example of selective serotonin reuptake inhibitors and venlafaxine in pregnancy.
Compare analyses of a pooled data set on the individual level with aggregate meta-analysis in a multi-database study. ⋯ Results of fixed effects meta-analysis and individual-based analyses of a pooled dataset were similar in this study on the association of SSRI/venlafaxine and cardiovascular birth defects. Country-optimized adjustment attenuated the estimates more than adjustment for common covariates only. When data are sparse pooled data on the individual level are needed for adjusted analyses. Copyright © 2016 John Wiley & Sons, Ltd.