Pharmacoepidemiology and drug safety
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Pharmacoepidemiol Drug Saf · Feb 2016
Preadmission use of renin-angiotensin blockers and rupture of abdominal aortic aneurysm: a nationwide, population-based study.
Rupture of abdominal aortic aneurysms (rAAA) is associated with high mortality. Use of angiotensin converting enzyme inhibitors (ACE-inhibitors) and angiotensin receptor blockers (ARBs) has been suggested to reduce the risk of rAAA. This nationwide, combined case-control and follow-up study aims to examine the possible impact of preadmission renin-angiotensin system blockade on the risk of rAAA and case fatality following rAAA. ⋯ Use of renin-angiotensin system blockade was not associated with a lower risk of rAAA or lower case fatality following rAAA.