Pharmacoepidemiology and drug safety
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Pharmacoepidemiol Drug Saf · Mar 2018
Comparative StudyTamsulosin and the risk of dementia in older men with benign prostatic hyperplasia.
Clinicians use tamsulosin, an α1-adrenoceptor antagonist, to manage symptomatic benign prostatic hyperplasia (BPH). Because α1-adrenoceptors are also present in the brain, the potential exists for adverse effects on cognitive functions. We explored the association between tamsulosin use and dementia risk. ⋯ Tamsulosin may increase the risk of dementia in older men with BPH.