American journal of obstetrics and gynecology
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Am. J. Obstet. Gynecol. · Aug 1981
Endotoxic shock in the primate: effects of aspirin and dipyridamole administration.
A primate model was utilized to study the cardiovascular and coagulation effects of endotoxic shock. The therapeutic effectiveness of drugs such as aspirin and dipyridamole, which diminish platelet aggregation and adherence, were evaluated. From the data, it appears that the kidney is a target organ in endotoxic shock, at least when a bolus injection of endotoxin is administered. ⋯ The changes in the coagulation profile were of less magnitude, and the fibrin degradation products appeared late in the group pretreated with aspirin as compared to the other groups. The combination of dipyridamole and aspirin was not as effective as aspirin alone in achieving the apparently protective effect. The study suggests that the administration of aspirin to patients with gram-negative infections may be beneficial.
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Am. J. Obstet. Gynecol. · Aug 1981
Bradycardia in the fetal baboon following paracervical block anesthesia.
In order to define the causal relationship between the use of local anesthetics and fetal bradycardia, paracervical block anesthesia (PCB) with lidocaine of 2-chloroprocaine was induced on 52 occasions to 27 pregnant baboons. The dosages were comparable to those used clinically on the basis of maternal body weight. On 40 occasions, PCB was induced with nonasphyxiated (normal) fetuses, 33% of which developed fetal bradycardia after PCB. ⋯ These levels were far below those associated with myocardial toxicity. The conclusion is that the fetal bradycardia subsequent to PCB is, in part, caused by a decrease in the oxygen available to the fetus secondary to an increase in uterine activity and a reduction in uteroplacental perfusion. This manifestation may occur at drug concentrations in both the mother and fetus that are far below toxic levels.