American journal of obstetrics and gynecology
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Am. J. Obstet. Gynecol. · Sep 1988
Randomized Controlled Trial Clinical TrialThe use of labetalol for attenuation of the hypertensive response to endotracheal intubation in preeclampsia.
Twenty-five women with preeclampsia who were scheduled to undergo cesarean section under general anesthesia were randomly assigned to either a labetalol pretreatment group (n = 15) or a control group (n = 10) who did not receive any antihypertensive therapy before the induction of anesthesia. Patients in the labetalol group received 20 mg of labetalol intravenously followed by 10 mg increments up to a total dose of 1 mg/kg, which resulted in moderate reductions in the maternal mean arterial pressure and heart rate with attenuation of the hypertensive and tachycardiac responses to laryngoscopy and endotracheal intubation. ⋯ The neonatal Apgar scores and umbilical arterial and venous pH and blood gas values were similar in the two groups. Side effects such as hypotension, bradycardia, and hypoglycemia were not seen in the neonates in the labetalol treatment group.
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A case of parenchymal pulmonary endometriosis, a very rare gynecologic problem, is presented. Hormonal suppressive therapy was accomplished by pregnancy. This patient has remained free of symptoms as she has been breast-feeding and amenorrheic. Long-term follow-up is essential because of the high recurrence rate.