American journal of obstetrics and gynecology
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Am. J. Obstet. Gynecol. · Sep 1993
Stimulation and inhibition of N-methyl-D-aspartate receptors in rats: developing a seizure model.
The objective of this study was to develop an experimental rat hippocampal seizure model based on the stimulatory effects of N-methyl-D-aspartate and to determine the inhibitory effects of MK-801 on N-methyl-D-aspartate-induced seizures. ⋯ Intracranial injection of 20 micrograms of N-methyl-D-aspartate produced reliable hippocampal seizure activity without mortality. MK-801 at a dose of 1 mg/kg injected intraperitoneally had significant inhibitory effects on this seizure model.