American journal of obstetrics and gynecology
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Am. J. Obstet. Gynecol. · Oct 1995
Clinical TrialFavorable hemodynamic effects of magnesium sulfate in preeclampsia.
Our purpose was to evaluate the hemodynamic effects of magnesium sulfate in preeclamptic and preterm labor patients. ⋯ Magnesium sulfate infusion appears to have a prolonged hemodynamic effect in the preeclamptic patient. Sustained reduction in systemic vascular resistance and an increase in cardiac index is found in patients with preeclampsia but not in preterm labor.
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Am. J. Obstet. Gynecol. · Oct 1995
Histologic evidence of old intrauterine bleeding is more frequent in prematurity.
Our purpose was to study the incidence and location of histologic evidence of intrauterine bleeding in preterm and term placentas. ⋯ Decidual bleeding is common in all clinical types of preterm birth and is most common in preterm preeclampsia and nonhypertensive abruption placentae. A clinical history of bleeding is not correlated with the presence of decidual hemosiderin. Bleeding in the basal plate is related to histologic evidence of chronic uteroplacental vascular pathologic processes, which in cases of spontaneous prematurity (premature rupture of membranes, preterm labor, nonhypertensive abruptio placentae) may be associated with decidual bleeding which occasionally may be clinically manifested as gestational bleeding.
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Am. J. Obstet. Gynecol. · Oct 1995
Relationship between placental histologic features and umbilical cord blood gases in preterm gestations.
Our purpose was to test the hypothesis that placental histologic lesions reflect abnormal placental respiratory function in preterm gestations. ⋯ Changes in umbilical vein and artery pH, PO2, and PCO2 are significantly related to lesions of uteroplacental vascular pathologic mechanisms and intraplacental thrombosis. Placental lesions may be associated with chronic fetal distress by altering fetal oxygen availability and acid-base status. Placental immaturity resulting from prematurity may be associated with inefficient placental respiratory function and an increased likelihood of cesarean delivery in cases of premature rupture of membranes or preterm labor. Altered fetal acid-base balance plus excess numbers of circulating nucleated erythrocytes suggests that placental respiratory function is functionally abnormal when these lesions are present and leads to fetal tissue hypoxia.
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Am. J. Obstet. Gynecol. · Oct 1995
Randomized Controlled Trial Comparative Study Clinical TrialDoes magnesium sulfate affect the length of labor induction in women with pregnancy-associated hypertension?
Our purpose was to determine whether seizure prophylaxis with magnesium sulfate prolongs induction of labor in women with pregnancy-associated hypertension. ⋯ Compared with phenytoin, magnesium sulfate seizure prophylaxis in women with pregnancy-associated hypertension does not prolong the induction of labor nor does it result in an increase in cesarean deliveries.
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Am. J. Obstet. Gynecol. · Oct 1995
Randomized Controlled Trial Clinical TrialThe effect of low-dose aspirin on pregnancies complicated by elevated human chorionic gonadotropin levels.
Our purpose was to determine whether elevated second-trimester human chorionic gonadotropin levels identify women likely to benefit from low-dose aspirin therapy. ⋯ Aspirin therapy increased birth weight in all women, especially in women with high human chorionic gonadotropin levels, partly by increasing gestational age at delivery. This observation needs to be confirmed by further studies.