American journal of obstetrics and gynecology
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Am. J. Obstet. Gynecol. · Feb 1997
Angiogenin: a marker for preterm delivery in midtrimester amniotic fluid.
Neovascularization is a response of tissue to ischemic damage. Placental ischemia is thought to underlie a significant portion of preterm deliveries. Our objective was to evaluate whether angiogenin, a potent inducer of neovascularization, is increased in midtrimester amniotic fluid of patients destined to be delivered preterm. ⋯ Midtrimester amniotic fluid angiogenin levels are elevated in patients with preterm delivery. This supports the theory that preexisting intrauterine ischemia and inflammation are important risk factors for preterm delivery and may be already present in the early midtrimester.
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Am. J. Obstet. Gynecol. · Feb 1997
Effects of prolonged hypoxemia on fetal renal function and amniotic fluid volume in sheep.
Our purpose was to determine the effects of prolonged hypoxemia on fetal renal function and amniotic fluid volume and composition. ⋯ During prolonged fetal hypoxemia in the absence of acidemia, fetal urine production is maintained, whereas the normal gestational increase in amniotic fluid volume is prevented, raising the possibility that intramembranous reabsorption of amniotic fluid is increased by hypoxemia.