American journal of obstetrics and gynecology
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Am. J. Obstet. Gynecol. · Jan 2002
Resistance artery smooth muscle function in pregnancy and preeclampsia.
The purpose of this study was to investigate whether the altered vascular resistance in pregnancy and preeclampsia results from alterations in intrinsic vascular smooth muscle properties or from external influences on vascular smooth muscle function. ⋯ Vascular smooth muscle calcium sensitivity is increased in preeclampsia.
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Am. J. Obstet. Gynecol. · Jan 2002
Randomized Controlled Trial Multicenter Study Clinical TrialAdverse perinatal outcomes are significantly higher in severe gestational hypertension than in mild preeclampsia.
The current literature emphasizes increased risk of adverse outcomes in the presence of proteinuria and hypertension. The objective of this study was to compare the frequency of adverse fetal outcomes in women who developed hypertensive disorders with or without proteinuria. ⋯ In women who have gestational hypertension or preeclampsia, increased rates of preterm delivery and delivery of small-for-gestational-age infants are present only in those with severe hypertension. In these women, the presence of proteinuria does not influence perinatal outcome.