American journal of obstetrics and gynecology
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Am. J. Obstet. Gynecol. · May 2006
Effect of magnesium sulfate on contractile force and intracellular calcium concentration in pregnant human myometrium.
This study was undertaken to evaluate the effects of magnesium sulfate (MgSO4) on contractile force and increases in free intracellular calcium concentration ([Ca2+]i) in human myometrial strips from pregnant women. ⋯ At a pharmacologic concentration (5 mmol/L), MgSO4 inhibits contractile response and [Ca2+]i in pregnant human myometrial strips by a pattern that is consistent with both extra- and intracellular mechanisms. At a suprapharmacologic concentration (10 mmol/L), the more immediate effect of MgSO4 is consistent with an extracellular mechanism. MgSO4 does not appear to interfere at the level of the calcium-calmodulin interface, since the [Ca2+]i/force relationship was not changed.
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Am. J. Obstet. Gynecol. · May 2006
Venous thromboembolism during pregnancy and the postpartum period: incidence, risk factors, and mortality.
The purpose of this study was to estimate the incidence, risk factors, and mortality from pregnancy-related venous thromboembolism. ⋯ The incidence of pregnancy-related venous thromboembolism was higher than generally quoted. Women ages 35 and older, black women, and women with certain medical conditions and obstetric complications appear to be at increased risk.
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Am. J. Obstet. Gynecol. · May 2006
Utility of Acute Physiology, Age, and Chronic Health Evaluation (APACHE III) score in maternal admissions to the intensive care unit.
A mean Acute Physiology, Age, and Chronic Health Evaluation (APACHE III) score of > 50 is associated with increased intensive care unit mortality rate in nonpregnant cardiac and trauma patients. The objective was to determine the usefulness of the APACHE III score in maternal admissions to an intensive care unit in a tertiary care center in an urban multicultural city. ⋯ The APACHE III is not associated with risk of intensive care unit-related maternal death.
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Am. J. Obstet. Gynecol. · May 2006
ReviewPreventive ethics for including women of childbearing potential in clinical trials.
We present a preventive ethics approach for including women of childbearing potential in clinical trials. ⋯ A comprehensive, preventive ethics approach to the ethical challenges in clinical trials related to the prevention and occurrence of pregnancy is essential for responsibly enrolling women of childbearing potential.
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Am. J. Obstet. Gynecol. · May 2006
Comparative StudyResponsiveness of the Pelvic Floor Distress Inventory (PFDI) and Pelvic Floor Impact Questionnaire (PFIQ) in women undergoing vaginal surgery and pessary treatment for pelvic organ prolapse.
This study was undertaken to evaluate the responsiveness of the Pelvic Floor Distress Inventory (PFDI) and Pelvic Floor Impact Questionnaire (PFIQ) in women with pelvic organ prolapse undergoing surgical and nonsurgical management. ⋯ The PFDI and PFIQ are responsive to change in women undergoing surgical and nonsurgical treatment for pelvic organ prolapse. The PFDI is more responsive than the PFIQ.