American journal of obstetrics and gynecology
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Am. J. Obstet. Gynecol. · May 1996
Randomized Controlled Trial Comparative Study Clinical TrialA pilot study of intravenous ondansetron for hyperemesis gravidarum.
We attempted to determine whether the antiemetic ondansetron would be more effective than promethazine in treating hyperemesis gravidarum. ⋯ This preliminary trial of ondansetron demonstrated no benefit over promethazine in patients hospitalized for hyperemesis gravidarum.
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Am. J. Obstet. Gynecol. · May 1996
Comparative StudyInterleukin-6 concentrations in umbilical cord plasma are elevated in neonates with white matter lesions associated with periventricular leukomalacia.
Periventricular leukomalacia, a common brain white matter lesion in preterm neonates, is a major risk factor for cerebral palsy. Recently, cytokines (i.e., tumor necrosis factor and interleukin-1(beta)) have been implicated as mediators for the development of periventricular leukomalacia. The purpose of this study was to examine the relationship between umbilical cord plasma levels of tumor necrosis factor-alpha, interleukin-1(beta), interleukin-6, and interleukin-1 receptor antagonist and the occurrence of periventricular leukomalacia in preterm neonates. ⋯ Interleukin-6 concentrations in umbilical cord plasma are elevated in neonates with periventricular leukomalacia-associated lesions. Our data support the hypothesis that periventricular leukomalacia may be the result of cytokine-mediated brain injury.
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Am. J. Obstet. Gynecol. · May 1996
Fetal branch pulmonary arterial vascular impedance during the second half of pregnancy.
Our purpose was to establish normal physiologic parameters in the fetal proximal and distal branch pulmonary arterial vascular impedance during the second half of pregnancy and to analyze relationships between proximal and distal pulmonary arterial blood velocity waveforms. ⋯ Fetal branch pulmonary arterial vascular impedance decreases significantly during the second half of pregnancy. The linear decrease in vascular impedance during the second trimester and in the beginning of the third trimester may be related to the growth of the lung and the increase in the number of resistance vessels. During the latter part of the third trimester pulmonary vascular impedance does not decrease further.
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Am. J. Obstet. Gynecol. · Apr 1996
Multicenter StudyCongenital diaphragmatic hernia: can prenatal ultrasonography predict outcome?
We wanted to establish whether prenatal ultrasonography predicts postnatal outcome in congenital diaphragmatic hernia. ⋯ In the majority of cases of isolated left congenital diaphragmatic hernia the prognostic value of fetal ultrasonography is too low to alter perinatal management.