Mediators of inflammation
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Mediators of inflammation · Jan 2013
Hypothermia reduces toll-like receptor 3-activated microglial interferon-β and nitric oxide production.
Therapeutic hypothermia protects neurons after injury to the central nervous system (CNS). Microglia express toll-like receptors (TLRs) that play significant roles in the pathogenesis of sterile CNS injury. ⋯ In addition, exposure to recombinant IFN- β and sodium nitroprusside, an NO donor, caused death of rat neuronal pheochromocytoma PC12 cells in a concentration-dependent manner after 24 h. Taken together, these results suggest that the attenuation of microglial production of IFN- β and NO by therapeutic hypothermia leads to the inhibition of neuronal cell death.
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Mediators of inflammation · Jan 2013
Toll-like receptor 9 promotes cardiac inflammation and heart failure during polymicrobial sepsis.
Aim was to elucidate the role of toll-like receptor 9 (TLR9) in cardiac inflammation and septic heart failure in a murine model of polymicrobial sepsis. ⋯ In polymicrobial sepsis TLR9 signalling is pivotal to cardiac inflammation and septic heart failure.