American journal of ophthalmology
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We examined and followed up 59 patients with conjunctival xerosis with a without classic Bitot's spots. Of these, 50 were responsive and nine were unresponsive to vitamin A. ⋯ Pigmentation and wrinkling were not useful diagnostic criteria and lesions isolated to the nasal corneoscleral limbus suggested a different diagnosis. At least some cases of nonresponsive conjunctival xerosis and Bitot's spots were probably sequelae of past vitamin A deficiency.