International archives of allergy and immunology
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Int. Arch. Allergy Immunol. · Nov 2001
Extraction of IgE-binding components of Helicobacter pylori by immunoblotting analysis in chronic urticaria patients.
An association between Helicobacter pylori and chronic urticaria has been suspected previously. An IgE-mediated pathway might be a possible link between H. pylori infection and chronic urticaria, and therefore we wanted to prepare an optimal H. pylori antigen to detect H. pylori-specific IgE antibodies in chronic urticaria patients. ⋯ Our findings suggest that although IgE-binding epitopes were found in H. pylori, H. pylori-specific IgE antibodies are not common in chronic urticaria, and the clinical significance of the IgE response is unclear.