International archives of allergy and immunology
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Int. Arch. Allergy Immunol. · Sep 2005
Comparative StudyCharacteristic features of allergic airway inflammation in a murine model of infantile asthma.
The pathophysiology of infantile asthma may differ from that in older children or in adults, partly because of the different immune response depending upon maturation. In adult mice, the sensitizing dose of antigen is known to be critical to the polarized development of helper T cell subsets and allergic airway inflammation. We wanted to know the characteristics of allergic airway inflammation of infantile asthma by developing a murine model. ⋯ GCM and, consequently, airway mucus hypersecretion may be an important component of allergic airway inflammation in infantile asthma.