International archives of allergy and immunology
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Int. Arch. Allergy Immunol. · Jan 2007
Comparative StudyInvolvement of galectin-9 in guinea pig allergic airway inflammation.
There is little information about the involvement of galectin-9 (Gal-9) in allergic inflammation. Thus, we investigated the role of Gal-9 in asthma model guinea pigs. ⋯ The present results provide evidence that Gal-9 is not involved in airway hypersensitivity, but is partly involved in prolonged eosinophil accumulation in the lung.
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Int. Arch. Allergy Immunol. · Jan 2007
Interleukin-16 inhibits immunoglobulin e production by B lymphocytes.
The increased production of IgE is a hallmark of atopic disorders. CD4+ T cells regulate the production of Immunoglobulin (Ig) E by B cells. Interleukin (IL) 16, a CD4+ specific cytokine, is highly expressed at sites of allergic inflammation. Our aim was to determine the effect of IL-16 on IgE production in atopic subjects. ⋯ These data show that IL-16 inhibits IgE production and therefore may play an important regulatory role in atopic disorders.
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Int. Arch. Allergy Immunol. · Jan 2007
Case ReportsRecurrent anaphylaxis due to non-ruptured hepatic hydatid cysts.
Hydatid disease, a parasitic infestation of humans, is endemic in the Mediterranean region, Australia, New Zealand and the Middle East, and mostly involves the liver. Anaphylactic reactions, which sometimes are the first manifestations of the disease, frequently occur due to cyst rupture after a minor/major trauma, though they may also be spontaneously seen on rare occasions. In extremely few studies, anaphylactic shock has been reported in patients without macroscopic rupture of the hydatid cysts. ⋯ We emphasize that physicians should be highly aware of hydatid disease as a possible etiology for seemingly idiopathic anaphylactic reactions, especially in endemic regions.