Statistical methods in medical research
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Stat Methods Med Res · Apr 2017
On the analysis of composite measures of quality in medical research.
Composite endpoints are commonplace in biomedical research. The complex nature of many health conditions and medical interventions demand that composite endpoints be employed. Different approaches exist for the analysis of composite endpoints. ⋯ Considering the BETTER trial data, the distinct effect GEE model struggled with convergence and the collapsed composite method estimated an effect, which was greatly attenuated compared to other models. All remaining models suggested an intervention effect of similar magnitude. In our simulation study, the binomial logistic regression model (corrected for possible over/under-dispersion), the linear regression model, the Poisson regression model (corrected for over-dispersion) and the common effect logistic GEE model appeared to be unbiased, with good type 1 error rates, power and convergence properties.