The American journal of the medical sciences
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Randomized Controlled Trial Clinical Trial
Sodium kinetics in white and black normotensive subjects: possible relevance to salt-sensitive hypertension.
The hypothesis that sodium (Na) kinetics are not a first order process was tested. Twelve normotensive white and 12 normotensive black men were given 10, 200, and 400 mmol/d Na as the chloride salt for 7 days in random order. All urine made was collected. ⋯ The data showed that T1/2 increases with increasing Na intake and is, therefore, dose-dependent or "zero" order. The effect of dose is more prominent in blacks than in whites; blacks accumulate more Na with increasing Na intake than whites. These data may have relevance for the pathogenesis of salt-sensitive hypertension in blacks.