The American journal of the medical sciences
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The Brugada syndrome is an inherited arrhythmogenic and nonstructural heart disease associated with an increased risk of sudden cardiac death from ventricular fibrillation. There are conflicting data about its prevalence and prognosis. Particularly, population-based studies are lacking in the United States and other countries. ⋯ Brugada-type electrocardiograms among middle-aged or elderly Japanese-American men are uncommon and are not associated with increased risk of either sudden death or total mortality.
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Metformin-associated lactic acidosis (MALA) is a rare but serious clinical entity. It is almost always seen in patients with a serious underlying medical disorder, most often a degree of renal impairment or other factors that are known to predispose to the lactic acidosis. ⋯ Early recognition of this condition and initiation of treatment are important. Bicarbonate hemodialysis is the treatment of choice.