The American journal of the medical sciences
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Review Comparative Study
Reporting of adherence to medication in recent randomized controlled trials of 6 chronic diseases: a systematic literature review.
International recommendations such as the CONSORT and International Conference on Harmonisation statements recognize patient adherence to prescribed treatment as an important aspect of a treatment's evaluation, but this issue is little assessed. ⋯ There is important variability in the assessment and reporting of medication adherence in published RCTs of pharmacological treatments of selected chronic diseases, for a given disease and across diseases. Standardization is advisable to allow for comparisons among studies.
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The prevalence of diabetes in the U. S. Hispanic population has grown to epidemic proportions. ⋯ Diabetes is diagnosed at an earlier age, and, for a multiplicity of reasons, Hispanics suffer from higher rates of diabetic complications and mortality. The etiology for the higher prevalence of diabetes and its complications is not clear, but it is thought to be related to genetic and environmental factors. In this manuscript, we review recent epidemiologic information on the prevalence, pathophysiology, and complications of diabetes, as well as the recommendations for the management of Hispanics with type 2 diabetes.
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Clinical Trial
Polymyxin B-immobilized fiber hemoperfusion with the PMX-05R column in elderly patients suffering from septic shock.
Direct hemoperfusion with the polymyxin B-immobilized fiber (PMX-20R) column has a positive effect on outcome in patients with sepsis or septic shock. The PMX-05R column has a low priming volume and has been used in pediatric patients with septic shock. The aim of the present study was to determine whether PMX-F treatment with the PMX-05R column is effective in elderly patients with septic shock. ⋯ Direct hemoperfusion with the PMX-05R column is effective in ameliorating clinical and laboratory abnormalities in elderly septic shock patients.