The American journal of the medical sciences
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Randomized Controlled Trial
Effects of spironolactone on long-term mortality and morbidity in patients with heart failure and mild or no symptoms.
The purpose of this study is to evaluate long-term effects of spironolactone, an affordable and widely used aldosterone receptor blocker, in patients with heart failure (HF) and mild or no symptoms. ⋯ Administration of spironolactone reduced the composite of death and cardiovascular hospitalization in patients with NYHA classes I to II HF. These results suggest that spironolactone could be beneficial when administered on top of optimal therapy among patients with HF and mild or no symptoms.