The American journal of the medical sciences
-
Calcitriol has the potential to counteract fibrotic diseases beyond its classical action of maintaining calcium and bone metabolism; however, its functional mechanism remains unknown. Autophagy-related gene 16-like 1 (Atg16l1) is one of the genes related to autophagy and is involved in protecting against fibrotic diseases. The present study aimed to explore the contribution of autophagy to the inhibition of calcitriol-induced hepatic fibrosis, as well as its potential molecular mechanism. ⋯ Calcitriol mitigates hepatic fibrosis partly through ATG16L1-mediated autophagy.
-
Numerous studies have explored the therapeutic potential of microRNA (miR) in myocardial infarction (MI) treatment. This study focuses on the role of miR-322-5p in MI, particularly in its regulatory interaction with B-cell translocation gene 2 (BTG2). ⋯ This study provides evidence that miR-322-5p protects against MI by suppressing BTG2 expression.
-
Observational Study
Estimated plasma volume status is a simple and quick tool that could help define the severity of patients with infection on arrival at the emergency department.
Infectious states are subtle and rapidly evolving conditions observed daily in the emergency department (ED), and their prognostic evaluation remains a complex clinical challenge. Recently, estimated plasma volume status (ePVS) has been suggested to have a prognostic role in conditions where volemic alteration is central to the pathophysiology. The aim of this study was to verify whether ePVS recorded at ED admission can provide prognostic indications of 30-day mortality in patients with infection. ⋯ ePVS recorded on ED admission of patients with infection was an independent predictor of risk for 30-day mortality.