Transfusion medicine
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Transfusion medicine · Aug 2016
Clinical TrialFibrinogen concentrate improves clot strength in patients with haematological malignancies requiring platelet transfusion.
Patients with bone marrow failure secondary to chemotherapy often develop thrombocytopenia and require platelet transfusion. Fibrinogen plays an important role in platelet aggregation and the establishment of the primary haemostatic plug. ⋯ Fibrinogen concentrate increased clot firmness to the same degree as platelet transfusion in patients with low platelet count requiring platelet transfusion.