Transfusion medicine
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Transfusion medicine · Aug 2019
Multicenter Study Clinical TrialSafety and effectiveness of a prothrombin complex concentrate in approved and off-label indications.
To evaluate the effectiveness and safety of prothrombin complex concentrates (PCCs) in approved and off-label indications. ⋯ 4F-PCC was effective as adjuvant treatment with an acceptable safety profile, not only for the emergent reversal of VKAs but also for refractory coagulopathy associated with major bleeding.