The American journal of psychiatry
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Randomized Controlled Trial Comparative Study Clinical Trial
A double-blind comparative study of clozapine and risperidone in the management of severe chronic schizophrenia.
This prospective, double-blind, multicenter, parallel-group study compared the efficacy and safety of therapeutic doses of clozapine and risperidone in patients with severe chronic schizophrenia and poor previous treatment response. ⋯ Clozapine showed superior efficacy over risperidone in this patient population. Both treatments were equally well tolerated as demonstrated through their adverse event profiles, although as expected clozapine was associated with a lower risk of extrapyramidal symptoms than risperidone.