The American journal of psychiatry
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Randomized Controlled Trial Comparative Study Clinical Trial
Reduction of nightmares and other PTSD symptoms in combat veterans by prazosin: a placebo-controlled study.
Prazosin is a centrally active alpha(1) adrenergic antagonist. The authors' goal was to evaluate prazosin efficacy for nightmares, sleep disturbance, and overall posttraumatic stress disorder (PTSD) in combat veterans. ⋯ These data support the efficacy of prazosin for nightmares, sleep disturbance, and other PTSD symptoms.