The American journal of psychiatry
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Clinical outcome of ECT in patients with major depression and comorbid borderline personality disorder.
Previous research suggests that the comorbidity of major depression with a personality disorder, especially borderline personality disorder, is associated with a poorer response to ECT. The authors compared the acute outcome of ECT in depressed patients with borderline personality disorder, with personality disorders other than borderline personality disorder, and with no personality disorder. ⋯ Patients with borderline personality disorder have a poorer acute response to ECT, but explanations for this finding remain elusive.
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Meta Analysis Comparative Study
Hippocampal volume and depression: a meta-analysis of MRI studies.
Several studies have found reduced hippocampal volume in patients with unipolar depression, but discrepancies exist. The authors performed a systematic review and meta-analysis of volumetric studies of the hippocampus in patients with mood disorders. ⋯ Hippocampal volume is reduced in patients with unipolar depression, maybe as a consequence of repeated periods of major depressive disorder. Bipolar patients did not seem to show a reduction in hippocampal volume, but this has been much less investigated.