The American journal of psychiatry
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
A randomized, double-blind, placebo-controlled trial of quetiapine in the treatment of bipolar I or II depression.
There is a major unmet need for effective options in the treatment of bipolar depression. ⋯ Quetiapine monotherapy is efficacious and well tolerated for the treatment of bipolar depression.
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Comparative Study
Longitudinal course of posttraumatic stress disorder and posttraumatic stress disorder symptoms in a community sample of adolescents and young adults.
Few studies have focused on the natural course of posttraumatic stress disorder (PTSD) and its determinants in samples of the general population. The authors examined determinants of remission and chronicity of PTSD and associations with other disorders in a prospective community sample. ⋯ PTSD is often a persistent and chronic disorder. Specific symptom clusters--especially avoidant symptoms--might be associated with the course of PTSD. In addition, the occurrence of new traumatic events differentiates PTSD cases with a chronic course from those with remission.
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The goal of this study was to develop a model of risk factors for posttraumatic stress disorder (PTSD) in a group of acutely burned children. ⋯ These findings support a model of complex etiology for childhood PTSD in which two independent pathways may be mediated by different biobehavioral systems.