European journal of human genetics : EJHG
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Eur. J. Hum. Genet. · Jan 1996
Case ReportsAutosomal recessive lamellar ichthyosis and acute lymphoblastic leukemia.
Autosomal recessive lamellar ichthyosis (ARLI) is a congenital disorder of keratinization, the gene of which has been mapped to chromosome 14q11. This band is also the breakpoint in various chromosomal rearrangements in T cell acute lymphoblastic leukemia (ALL). ⋯ High resolution banding showed no abnormality or rearrangement involving chromosome 14. To our knowledge, this is the first description of the occurrence of the two conditions in one patient.