Current opinion in nephrology and hypertension
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There is increasing evidence that the sodium pump plays a role in essential hypertension. Recent publications have focused on intrinsic alterations in pump activity, external modification of pump activity by circulating inhibitors, and endothelial mediation of endogenous inhibitor effects on the vascular response. Hence, this review focuses on these areas. Although there is intriguing evidence that alterations in sodium pump activity might contribute to the pathogenesis of hypertension, in at least some sodium-sensitive models and some patients with essential hypertension, the evidence remains circumstantial and areas of substantial controversy exist.
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Curr. Opin. Nephrol. Hypertens. · Jan 1994
Review Comparative StudyMolecular and cellular biology of vasopressin and oxytocin receptors and action in the kidney.
The molecular cloning and characterization of receptors for [Arg8] vasopressin and oxytocin were recently accomplished. These receptors form a subfamily among the large number of guanine nucleotide-binding regulatory protein (G protein)-coupled receptors with seven transmembrane domains. ⋯ Carrier detection and early diagnosis of affected male infants are available and can avert the physical and mental retardation that are the consequences of episodes of dehydration. Together with the recent cloning of the vasopressin-regulated water channels in the apical membrane of the collecting tubule, these developments will enable direct investigation of the mammalian concentrating mechanism.