Current opinion in nephrology and hypertension
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Curr. Opin. Nephrol. Hypertens. · Nov 2003
ReviewPolyomavirus nephropathy: morphology, pathophysiology, and clinical management.
Viral nephropathies, particularly those caused by polyomaviruses of the BK-virus strain, are serious complications following renal transplantation. The review will highlight the morphological, pathophysiological and clinical aspects of BK-virus nephropathy. New patient management strategies are discussed. ⋯ BK-virus nephropathy is a significant complication following renal transplantation. Recent advances have improved our understanding of the morphological changes, potential risk factors and patient management strategies would be optimized. The availability of quantitative viral load measurements now offers the opportunity for a more accurate and timely clinical intervention.