Osteoarthritis and cartilage
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Osteoarthr. Cartil. · Nov 1997
Effects of diacerhein in an accelerated canine model of osteoarthritis.
To determine whether diacerhein has a disease-modifying effect in an accelerated canine model of osteoarthritis. ⋯ The differences between the diacerhein group and untreated OA controls, even though not statistically significant, suggest that diacerhein was active in this rapidly progressive model of OA. Because changes associated with initiation of OA may be different than those associated with progression, whether diacerhein has a disease-modifying effect should be examined in a less rapidly progressive model.