Osteoarthritis and cartilage
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Osteoarthr. Cartil. · Jan 1998
Effects of diacerhein on granuloma induced cartilage breakdown in the mouse.
Diacerhein, an anti-osteoarthritic agent, was tested for its ability to suppress synthesis of proinflammatory cytokines in a model of granuloma-induced cartilage breakdown. ⋯ The mechanism of the chondroprotective effects of diacerhein is not understood but may be explained by a reduction in the concentrations of proinflammatory cytokines.