Osteoarthritis and cartilage
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Osteoarthr. Cartil. · Nov 2001
Moderation of iodoacetate-induced experimental osteoarthritis in rats by matrix metalloproteinase inhibitors.
To determine the effect of matrix metalloproteinase (MMP) inhibitors in mono-iodoacetate-induced arthritis in rats. ⋯ MMP inhibitors are partially protective against cartilage and subchondral bone damage induced by iodoacetate. These results support an important role for MMPs in mediating the joint damage in this model of arthritis.