Osteoarthritis and cartilage
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Osteoarthr. Cartil. · Feb 2010
Randomized Controlled TrialThe effect of oral salmon calcitonin delivered with 5-CNAC on bone and cartilage degradation in osteoarthritic patients: a 14-day randomized study.
The aim of this study was to investigate the pharmacokinetic and pharmacodynamic parameters of oral salmon calcitonin (oSCT) administered over 14 days to men and women presenting with osteoarthritis (OA). ⋯ oSCT given twice daily with a pre-dinner and morning fasting dosing resulted in reductions in markers of bone resorption and cartilage degradation.
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Osteoarthr. Cartil. · Feb 2010
Multicenter StudyThe relation of femoral notch stenosis to ACL tears in persons with knee osteoarthritis.
A significant risk factor for anterior cruciate ligament (ACL) tears in young athletes is a reduced femoral Notch Width Index (NWI). The purpose of this study was to test if persons with knee osteoarthritis (OA) and ACL tears have smaller NWI independent of prior joint injury and osteophyte volume. ⋯ We identified a smaller NWI in participants with knee OA and ACL tears. Further longitudinal investigation is necessary to determine this as an independent risk factor.
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Osteoarthr. Cartil. · Feb 2010
Racial differences in osteoarthritis pain and function: potential explanatory factors.
This study examined factors underlying racial differences in pain and function among patients with hip and/or knee osteoarthritis (OA). ⋯ Factors explaining racial differences in pain and function were largely psychological, including arthritis self-efficacy, affect, and use of emotion-focused coping. Self-management and psychological interventions can influence these factors, and greater dissemination among African Americans may be a key step toward reducing racial disparities in pain and function.