Osteoarthritis and cartilage
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Osteoarthr. Cartil. · Jun 2011
Multicenter StudyPre-operative expectation predicts 12-month post-operative outcome among patients undergoing primary total hip replacement in European orthopaedic centres.
Patients' expectations of surgery may be related to outcomes of joint replacement. The aims of this study were to: (1). Identify patient characteristics associated with pre-operative expectations of total hip replacement (THR); (2). Explore whether pre-operative expectations predict surgical outcomes 12-months post-THR. ⋯ There is large variation in patients' pre-operative expectations of THR. Greater numbers of pre-operative expectations were associated with improvement following THR. This appears to be driven more by stiffness and function. These findings have implications for informed patient-clinician decision-making.
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A neuropathic pain (NP) questionnaire may facilitate the identification of a neuropathic component to osteoarthritis (OA) pain. An existing questionnaire, the painDETECT, was modified for use in knee OA and administered to measure the prevalence and correlates of NP symptoms among adults with this condition. ⋯ Among older adults with chronic symptomatic knee OA, over one-quarter had NP symptoms localized to their knees using the mPD-Q. The mPD-Q may facilitate the identification of a neuropathic component to pain in adults with knee OA who may benefit from further evaluation and/or treatment for NP.
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Osteoarthr. Cartil. · Jun 2011
Test-retest reliability of Quantitative Sensory Testing in knee osteoarthritis and healthy participants.
Quantitative Sensory Testing (QST), which assesses somatosensory function by recording participant's responses to external stimuli of controlled intensity, is a useful tool to provide insight into the complex pathophysiology of osteoarthritis (OA) pain. However, QST is not commonly used in rheumatology because the test-retest reliability properties of QST in OA patients have not yet been established. ⋯ Pressure pain thresholds were found to be the least variable measurement, as median thresholds did not differ significantly over the 1 week period and the results were highly correlated. This provides support for the inclusion of pressure algometry in studies assessing pain perception abnormalities in OA.
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Osteoarthr. Cartil. · Jun 2011
Randomized Controlled Trial Multicenter StudyLong-term open-label study of tanezumab for moderate to severe osteoarthritic knee pain.
This study was designed to evaluate the long-term safety and effectiveness of repeated doses of the humanized anti-nerve growth factor antibody, tanezumab, during open-label treatment of patients with OA knee pain. ⋯ Repeated injections of tanezumab in patients with moderate to severe knee OA provide continued pain relief and improved function with a low incidence of side effects. Additional studies to define the efficacy and duration of pain reduction and to provide a more complete assessment of long-term safety are warranted.