Osteoarthritis and cartilage
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Osteoarthr. Cartil. · Aug 2012
Comparative StudyConsequences of handling missing data for treatment response in osteoarthritis: a simulation study.
To understand how handling of missing data influences the statistical power and bias of treatment effects in randomised controlled trials of painful knee osteoarthritis (OA). ⋯ Multiple imputation of missing data may be used to decrease bias/MSE and increase power in OA trials. These results can guide investigators in the choice of outcome measures and especially how missing data can be handled.