Osteoarthritis and cartilage
-
Osteoarthr. Cartil. · May 2013
The association between reduced knee joint proprioception and medial meniscal abnormalities using MRI in knee osteoarthritis: results from the Amsterdam osteoarthritis cohort.
Osteoarthritis (OA) of the knee is characterized by pain and activity limitations. In knee OA, proprioceptive accuracy is reduced and might be associated with pain and activity limitations. Although causes of reduced proprioceptive accuracy are divergent, medial meniscal abnormalities, which are highly prevalent in knee OA, have been suggested to play an important role. No study has focussed on the association between proprioceptive accuracy and meniscal abnormalities in knee OA. ⋯ This is the first study showing that reduced proprioceptive accuracy is associated with medial meniscal abnormalities in knee OA. The study highlights the importance of meniscal abnormalities in understanding reduced proprioceptive accuracy in persons with knee OA.
-
Osteoarthr. Cartil. · May 2013
Randomized Controlled TrialResponsiveness of the Intermittent and Constant Osteoarthritis Pain (ICOAP) scale in a trial of duloxetine for treatment of osteoarthritis knee pain.
To assess the change in the Intermittent and Constant Osteoarthritis Pain (ICOAP)-scale scores in patients taking duloxetine or placebo and to characterize the responsiveness of the ICOAP by comparing the effect size associated with its scales to effect sizes seen with other pain scales used in this study. ⋯ ClinicalTrial.gov Identifier: NCT01018680.
-
Osteoarthr. Cartil. · May 2013
Radiofrequency (RF) coil impacts the value and reproducibility of cartilage spin-spin (T2) relaxation time measurements.
T2 (spin-spin) relaxation time is frequently used for compositional assessment of articular cartilage. However little is known about the influence of magnetic resonance (MR) system components on these measurements. The reproducibility and range of cartilage T2 values were evaluated using different extremity radiofrequency (RF) coils with potential differences in flip angle uniformity and signal-to-noise ratio (SNR). ⋯ SNR varied spatially (significant) depending upon coil, but refocusing flip angle only slightly. With higher SNR, significantly longer T2 values were measured for deep (all plates) and global (MT, cMF) cartilage. T2 values varied by depth and plate, in agreement with prior studies.
-
Osteoarthr. Cartil. · May 2013
Chondrocyte death after drilling and articular screw insertion in a bovine model.
Intra-articular screws are used for internal fixation of osteochondral fragments after fracture or osteochondritis dissecans. This causes cartilage injury potentially leading to chondrocyte death. We have visualised/quantified the hole and zone of cell death (ZCD) in cartilage after drilling/insertion of various articular screws. ⋯ Cartilage injury during intra-articular screw fixation caused a ZCD around the hole irrespective of screw design. Saline irrigation significantly reduced the ZCD from drilling into cartilage.