Osteoarthritis and cartilage
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Osteoarthr. Cartil. · Jun 2013
Real-time assessment of bone metabolism in small animal models for osteoarthritis using multi pinhole-SPECT/CT.
Destructive techniques such as histology and biochemical assays are still regarded the gold standard to study the effects of novel therapies or etiologic aspects of osteoarthritis in small animal models. These techniques are time-consuming and require many animals. Multi-pinhole single photon emission computed tomography (MPH-SPECT) is a relatively novel, high resolution imaging technique which enables assessment of biological processes in real-time and thus it might provide a good substitute for destructive assessment techniques. ⋯ MPH-SPECT/CT proved to be a highly sensitive assessment technique for experimental osteoarthritis in small animal models, detecting real-time changes in bone turnover at a very early time point, which might make it a valuable technique to measure the direct effect of interventional strategies on osteoarthritis.
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Osteoarthr. Cartil. · Jun 2013
Multicenter StudyPhysical activity, alignment and knee osteoarthritis: data from MOST and the OAI.
To determine the effect of physical activity on knee osteoarthritis (OA) development in persons without knee injury and according to knee alignment. ⋯ Physical activity in the highest quartile did not affect the risk of developing OA.