Osteoarthritis and cartilage
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Osteoarthr. Cartil. · Feb 2015
Review Meta AnalysisElectrical stimulation for pain relief in knee osteoarthritis: systematic review and network meta-analysis.
To investigate the efficacy of different electrical stimulation (ES) therapies in pain relief of patients with knee osteoarthritis (OA). ⋯ LevelⅡ, systematic review and network meta-analysis of RCTs.
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Osteoarthr. Cartil. · Feb 2015
Randomized Controlled TrialEffects of total and regional fat loss on plasma CRP and IL-6 in overweight and obese, older adults with knee osteoarthritis.
To describe associations between total and regional body fat mass loss and reduction of systemic levels of inflammation (C-reactive protein (CRP) and interleukin-6 (IL-6)) in obese, older adults with osteoarthritis (OA), undergoing intentional weight loss. ⋯ NCT00381290.
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Osteoarthr. Cartil. · Feb 2015
Airflow accelerates bovine and human articular cartilage drying and chondrocyte death.
Exposure of articular cartilage to static air results in changes to the extracellular matrix (ECM) and stimulates chondrocyte death, which may cause joint degeneration. However during open orthopaedic surgery, cartilage is often exposed to laminar airflow, which may exacerbate these damaging effects. We compared drying in static and moving air in terms of cartilage appearance, hydration and chondrocyte viability, and tested the ability of saline-saturated gauze to limit the detrimental effects of air exposure. ⋯ Airflow significantly increased articular cartilage dehydration and chondrocyte death compared to static air. As laminar airflow is routinely utilised in operating theatres, it is essential that articular cartilage is kept wet via irrigation or by covering with saline-saturated gauze to prevent chondrocyte death.