Osteoarthritis and cartilage
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Osteoarthr. Cartil. · Mar 2014
Practice GuidelineOARSI guidelines for the non-surgical management of knee osteoarthritis.
To develop concise, up-to-date, patient-focused, evidence-based, expert consensus guidelines for the management of knee osteoarthritis (OA), intended to inform patients, physicians, and allied healthcare professionals worldwide. ⋯ These evidence-based consensus recommendations provide guidance to patients and practitioners on treatments applicable to all individuals with knee OA, as well as therapies that can be considered according to individualized patient needs and preferences.
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Osteoarthr. Cartil. · Mar 2014
Detection of cartilage damage in femoroacetabular impingement with standardized dGEMRIC at 3 T.
This study aimed at identifying the optimal threshold value to detect cartilage lesions with Standardized delayed Gadolinium-Enhanced MRI of Cartilage (dGEMRIC) at 3 T and evaluate intra- and inter-observer repeatability. ⋯ Standardized dGEMRIC at 3 T is accurate in detecting cartilage damage and could improve preoperative assessment in femoroacetabular impingement (FAI). As cartilage lesions in FAI are localized, visual inspection of the Standardized dGEMRIC maps is more accurate than an average z for the acetabular cartilage.
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Osteoarthr. Cartil. · Feb 2014
Comparative StudyComparative responsiveness of outcome measures for total knee arthroplasty.
The aim of this study was to compare the responsiveness of various patient-reported outcome measures (PROMs) and clinician-reported outcomes following total knee arthroplasty (TKA) over a 2-year period. ⋯ Outcome measures differ considerably in responsiveness, especially beyond one year post-operatively. Joint-specific outcome measures are more responsive than clinician-reported or generic health outcome tools. The FJS-12 was the most responsive of the tools assessed; suggesting that joint awareness may be a more discerning measure of patient outcome than traditional PROMs.
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Osteoarthr. Cartil. · Feb 2014
The relationship between knee pain characteristics and symptom state acceptability in people with knee osteoarthritis.
To examine the association between osteoarthritis (OA) pain characteristics and symptom acceptability. ⋯ In a community cohort with symptomatic knee OA, both the severity and predictability of intermittent knee pain contributed to symptom state acceptability. Unpredictable intermittent knee pain was more likely to be associated with an unacceptable symptom state than predictable intermittent pain. Research is warranted to elucidate potentially modifiable determinants of unpredictable intermittent pain in people with knee OA.
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Osteoarthr. Cartil. · Jan 2014
Identification and characterisation of osteoarthritis patients with inflammation derived tissue turnover.
Osteoarthritis (OA) is a degenerative disease with a subset of patients experiencing joint inflammation, but C-reactive protein (CRP) has shown limited use in OA as a diagnostic marker. The aim was to identify subpopulations of patients with high or low levels of acute (high sensitive CRP (hsCRP)) and/or matrix metalloproteinase (MMP) derived inflammation (CRPM) and investigate the subpopulations' association with biomarkers of collagen degradation and Kellgren-Lawrence (KL) score. ⋯ A bigger proportion of patients were elevated in CRPM compared to hsCRP, indicating MMP-derived inflammation as a component of OA. Moreover, the levels of MMP-degraded collagens differed between the subgroups segregated by inflammation, indicating distinctively different subpopulation selected by inflammation.