Osteoarthritis and cartilage
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Osteoarthr. Cartil. · Aug 2013
Randomized Controlled TrialKnee joint stabilization therapy in patients with osteoarthritis of the knee: a randomized, controlled trial.
To investigate whether an exercise program, initially focusing on knee stabilization and subsequently on muscle strength and performance of daily activities is more effective than an exercise program focusing on muscle strength and performance of daily activities only, in reducing activity limitations in patients with knee osteoarthritis (OA) and instability of the knee joint. ⋯ Both exercise programs were highly effective in reducing activity limitations and pain and restoring knee stability in knee OA patients with instability of the knee. In knee OA patients suffering from knee instability, specific knee joint stabilization training, in addition to muscle strengthening and functional exercises, does not seem to have any additional value. Dutch Trial Register (NTR) registration number: NTR1475.
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Osteoarthr. Cartil. · Aug 2013
Randomized Controlled TrialRandomized double-blind crossover study of the efficacy of a tart cherry juice blend in treatment of osteoarthritis (OA) of the knee.
To assess the efficacy of tart cherry juice in treating pain and other features of knee osteoarthritis (OA). ⋯ Tart cherry juice provided symptom relief for patients with mild to moderate knee OA, but this effect was not significantly greater than placebo. Tart cherry juice lowered hsCRP levels and this effect was associated with improved WOMAC scores.
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Osteoarthr. Cartil. · Jul 2013
MicroRNA-558 regulates the expression of cyclooxygenase-2 and IL-1β-induced catabolic effects in human articular chondrocytes.
Cyclooxygenase-2 (COX-2) is a major prostaglandin E2 (PGE2) synthetic enzyme and is involved in the pathogenesis of chronic inflammation and pain in osteoarthritis (OA). The objective of this study was to directly address whether microRNA (miR)-558 can control the interleukin (IL)-1β-mediated induction of COX-2 and catabolic effects in human articular chondrocytes. ⋯ These findings demonstrated that cartilage homeostasis is influenced by miR-558, which directly targets COX-2 and regulates IL-1β-stimulated catabolic effects in human chondrocytes.
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Osteoarthr. Cartil. · Jun 2013
Real-time assessment of bone metabolism in small animal models for osteoarthritis using multi pinhole-SPECT/CT.
Destructive techniques such as histology and biochemical assays are still regarded the gold standard to study the effects of novel therapies or etiologic aspects of osteoarthritis in small animal models. These techniques are time-consuming and require many animals. Multi-pinhole single photon emission computed tomography (MPH-SPECT) is a relatively novel, high resolution imaging technique which enables assessment of biological processes in real-time and thus it might provide a good substitute for destructive assessment techniques. ⋯ MPH-SPECT/CT proved to be a highly sensitive assessment technique for experimental osteoarthritis in small animal models, detecting real-time changes in bone turnover at a very early time point, which might make it a valuable technique to measure the direct effect of interventional strategies on osteoarthritis.
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Osteoarthr. Cartil. · Jun 2013
Multicenter StudyPhysical activity, alignment and knee osteoarthritis: data from MOST and the OAI.
To determine the effect of physical activity on knee osteoarthritis (OA) development in persons without knee injury and according to knee alignment. ⋯ Physical activity in the highest quartile did not affect the risk of developing OA.