Osteoarthritis and cartilage
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Osteoarthr. Cartil. · Nov 2012
Rebamipide attenuates pain severity and cartilage degeneration in a rat model of osteoarthritis by downregulating oxidative damage and catabolic activity in chondrocytes.
The objectives were to investigate the in vivo effects of treatment with rebamipide on pain severity and cartilage degeneration in an experimental model of rat osteoarthritis (OA) and to explore its mode of action. ⋯ The results show the inhibitory effects of rebamipide on pain production and cartilage degeneration in experimentally induced OA. The suppression of oxidative damage and the restoration of extracellular matrix homeostasis of articular chondrocyte suggest that rebamipide is a potential therapeutic strategy for OA.
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Osteoarthr. Cartil. · Oct 2012
Rasch analysis of the intermittent and constant osteoarthritis pain (ICOAP) scale.
The intermittent and constant osteoarthritis pain (ICOAP) questionnaire was developed to assess two forms of pain reported by people with osteoarthritis: intermittent and constant pain. Studies examining its measurement qualities have provided some support for its use as separate and total scales. However, it has not been previously evaluated using Rasch analysis. The current study examined the fit between data obtained from the ICOAP questionnaire and the Rasch model to determine whether it meets the requirements of interval-level measurement. ⋯ The results support the use of Constant and Intermittent subscales as unidimensional measures of pain. The Total scale can be adapted to improve fit to the Rasch model, but there are concerns over participant misfit.
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Osteoarthr. Cartil. · Oct 2012
Comparative StudyA new method to analyze dGEMRIC measurements in femoroacetabular impingement: preliminary validation against arthroscopic findings.
To validate a new method to analyze delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) measurements in the hip for early assessment of cartilage defects in femoroacetabular impingement (FAI). ⋯ Standardized dGEMRIC can increase the sensitivity in detecting abnormal cartilage in FAI and has the potential to improve the clinical interpretation of dGEMRIC measurements in FAI, by removing the effect of inter- and intra-patient T1 variability.
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Osteoarthr. Cartil. · Oct 2012
Review Meta AnalysisQuantitative sensory testing in painful osteoarthritis: a systematic review and meta-analysis.
To systematically review the use of quantitative sensory testing (QST) in pain characterisation (phenotyping) in osteoarthritis (OA). ⋯ QST of PPTs demonstrated good ability to differentiate between people with OA and healthy controls. Lower PPTs in people with OA in affected sites may suggest peripheral, and in remote sites central, sensitisation. PPT measurement merits further evaluation as a tool for phenotyping OA pain.
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Osteoarthr. Cartil. · Oct 2012
Randomized Controlled Trial Comparative StudyComparative effectiveness of alternative clinical pathways for primary hip and knee joint replacement patients: a pragmatic randomized, controlled trial.
Total hip replacement (THR) and total knee replacement (TKR) (arthroplasty) surgery for end-stage osteoarthritis (OA) are ideal candidates for optimization through an algorithmic care pathway. Using a comparative effectiveness study design, we compared the effectiveness of a new clinical pathway (NCP) featuring central intake clinics, dedicated inpatient resources, care guidelines and efficiency benchmarks vs. the standard of care (SOC) for THR or TKR. ⋯ While effect sizes were small compared with major effects of the surgery itself, an evidence-informed clinical pathway can improve health related quality of life (HRQoL) of hip and knee arthroplasty patients with degenerative joint disorder in routine clinical practice for up to 12 months post-operatively. CLINICALTRIALS.GOV IDENTIFIER: NCT00277186.