Revista chilena de infectología : órgano oficial de la Sociedad Chilena de Infectología
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Rev Chilena Infectol · Dec 2011
Review[Cells with immunoregulatory properties and their impact in the pathogenesis of sepsis].
Sepsis, defined as a systemic inflammatory response syndrome caused by an infection, is a significant cause of mortality worldwide. It is currently accepted that death associated to sepsis is due to an immune hyperactivation state involving the development of a broad proinflammatory response along with alterations in the coagulation system. ⋯ The purpose of this review is to summarize current mechanisms that explain the pathogenesis of sepsis, underlying the role that cells with immunoregulatory properties play during the course of this complex syndrome. A better understanding of these processes will contribute in the search of more successful therapeutic strategies.