Revista chilena de infectología : órgano oficial de la Sociedad Chilena de Infectología
-
Rev Chilena Infectol · Apr 2012
Review[Daptomycin: pharmacological characteristics and its role in the treatment of gram positive infections].
Daptomycin recently made available in Chile, belongs to a new family of antimicrobials known as lypopeptides. Daptomycin has a unique mechanism of action and a potent bactericidal activity over susceptible agents. ⋯ Ongoing trials suggest that daptomycin is also useful in the treatment of other infections such as osteomyelitis, biofilm producing infections, and in immunocompromised patients, particularly onco-hematologic patients. The main adverse reaction associated with daptomycin use is myopathy, usually mild and reversible.
-
Rev Chilena Infectol · Apr 2012
[Total globulins and lymphocyte count as markers of mortality in sepsis and septic shock].
There are no studies probing if patients in sepsis or septic shock with lower levels of total plasmatic globulins and/or lymphocyte count have higher mortality. ⋯ Lymphocyte count is early and independently associated with increased mortality in patients with sepsis or septic shock.